By submitting a comment you agree to abide by our Terms and Community Guidelines. The surgeon and infectious disease physician agreed that her erythema was an allergic reaction to the Dermabond. Kanerva L, Lauerma A, Estlander T, Alanko K, Henriks-Eckerman ML, Jolanki R. Am J Contact Dermat. Desai, Naman S. Of the 1145 patients included in the study, 32 (2.8%) patients were referred to dermatologists for suspected ACD after the use of a topical skin adhesive in the foot and ankle surgery, and 29 (2.5%) patients were diagnosed with ACD. Belsito, D. V. The diagnostic evaluation, treatment, and prevention of allergic contact dermatitis in the new millennium. This creates a functional glue when placed on the skin. Hysterectomy Defined Hysterectomy Facts Laparoscopic Hysterectomy Vaginal Hysterectomy Abdominal Hysterectomy Robotic . Lee E, Elzomor A, Zwemer C, Chen A, Thakkar PG. Park, Y. H., Song, J. H., Choi, G. W. & Kim, H. J. Generally, very few complications are associated with Dermabond and are usually related to application techniques. Incidence and risk factor of allergic contact dermatitis to 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives, https://doi.org/10.1038/s41598-021-03319-3. & Pawlik, T. M. STROBE reporting guidelines for observational studies. Although cyanoacrylates traditionally have been associated with low rates of sensitization, allergic contact dermatitis (ACD) to Dermabond products is being increasingly reported after orthopedic surgery. You are using a browser version with limited support for CSS. Bouten, P. J. et al. The distinction between infection and contact dermatitis is critical. 6rT(NQoQar?S<. HHS Vulnerability Disclosure, Help So hang in there. endstream endobj 135 0 obj <>stream I had an allergic reaction to dermabond after surgery (lipoma removal-23 incisions between knee and under breasts). Clin Case Studie Rep 1: DOI: 10.15761/CCSR.1000102. 2018 Gorski J. This study has two limitations. Latex allergies arise from an allergic reaction to products containing latex. Hostname: page-component-75b8448494-spc8s Allergic reactions to 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, NJ) are rare in the medical literature; there is only one published report.1 There are, however, scattered anecdotal reports of allergies to Dermabond on the Internet. 0000006767 00000 n Arthur W. Perry, MD, Michael Sosin, Severe Allergic Reaction to Dermabond, Aesthetic Surgery Journal, Volume 29, Issue 4, July 2009, Pages 314316, https://doi.org/10.1016/j.asj.2009.02.019. Dermabond was first approved by the US Food and Drug Administration in 1998 and has steadily increased in popularity. Dermabond is a liquid topical skin adhesive containing a monomeric 2-octyl cyanoacrylate formulation and the colorant D&C Violet #2 which should slough off with desquamation of the epidermis 7-14 days after application. Close this message to accept cookies or find out how to manage your cookie settings. The difference in the incidence of ACD between ingredients or products was analyzed using the chi-square test. The authors declare no competing interests. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Subsequent dermatologic evaluation confirmed the suspicion of an allergic reaction to Dermabond. The increasing popularity of Dermabond in the gynaecologic operating room stems from its ease of use to close port site incisions at the end of laparoscopic surgery. 0000060590 00000 n Care 20, 219223 (2004). further to my allergic reaction on Fri. HysterSisters Takes On Partner To Manage Continued Growth And Longevity. Chalmers, B. P. et al. 69, 763781 (2012). Dermabond is a liquid adhesive that contains the monomer of 2-octyl cyanocrylate (at a concentration of 94%). Ricci, Joseph A. Collaborations, Submit 2016 Mar-Apr;27(2):75-6. doi: 10.1097/DER.0000000000000163. Blanchet, Nadia https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD004287.pub4/ Farion K, Osmond MH, Hartling L, et al. The use of dermabond(R) as an adjunct to wound closure after total knee arthroplasty: Examining immediate post-operative wound drainage. Dermatitis. A, Preoperative view of a 36-year-old woman. These may include: Post-surgical rashes often go away when your skin is no longer in contact with the irritant. Additional components of Dermabond include plasticizers that aid in the flexibility of the wound during the healing process, stabilizers to prolong the shelf life, and polymerization inhibitors to delay the transition of the product from liquid to solid.2 The polymer hydrolyzes in the body, creating formaldehyde, which causes inflammation. Systemic steroids are the mainstay of treatment; however, topical petrolatum-based steroids not only treat symptoms but also dissolve the Dermabond. Polymerized cyanoacrylate degrades into substances such as cyanoacetate and formaldehyde that may produce skin inflammation if accumulated in surrounding tissue [13]. Quinn, J. et al. Results: 2017;77(6):414-415. In the trend of increasing the use of topical skin adhesives, these findings will help orthopedic surgeons attempt to use topical skin adhesives to predict ACD and provide information to patients. Here we report a case of allergic reaction secondary to use of Dermabond at Mount Sinai Hospital in New York, NY. Elzomor, Amir Topical skin adhesives were applied according to the instruction manual of each product. 0000004069 00000 n Singer AJ, Quinn JV, Hollander JE (2008) The cyanoacrylate topical skin adhesives. to worldwide, enabling them to utilize available resources effectively. Clipboard, Search History, and several other advanced features are temporarily unavailable. All patients underwent foot and ankle surgeries, which were performed by two orthopedic surgeons. Longer-chained cyanoacrylates, such as the 2-octyl cyanoacrylate monomer present in Dermabond, releases less degradation products than the short-chained monomers thus producing less potential histotoxicity. Tissue adhesives for closure of surgical incisions. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Unlike 2-octyl cyanoacrylate, to the best of our knowledge, there has been no study on the incidence of ACD in n-butyl cyanoacrylate topical skin adhesives. 2014. Coover HW, Joyner FB, Shearer NH, Wicker TH (1959) Chemistry and performance of cyanoacrylate adhesives. PDF Allergic reaction to Dermabond in gynaecologic surgery - OAText Skin hypersensitivity following application of tissue adhesive (2-octyl cyanoacrylate). Y.H.P. To date, ACD to topical skin adhesives has been continuously reported in case reports of sporadic events, but systematic studies on their incidence and risk factors have been limited. The adhesive property of the compound methyl 2-cyanoacrylate was first described in the literature by H.W. eCollection 2021. Over several decades, skin staples and sutures have been regarded as a common method for skin closure. With the escalation in Dermabond usage, which can be attributed to its speed and convenience, more allergic reactions are anticipated. 2021 Jun 15;34(6):736-738. doi: 10.1080/08998280.2021.1935140. 182 0 obj <>stream Gearhart, Peter A. Allergic Contact Dermatitis to Dermabond Prineo After Elective Orthopedic Surgery. Allergy 64, 801806 (2009). A severe allergic reaction can be seen; erythema and pruritis are both present along the incisions where Dermabond was applied. Severe Allergic Contact Dermatitis to Dermabond Prineo, a Topical Skin Adhesive of 2-Octyl Cyanoacrylate Increasingly Used in Surgeries to Close Wounds. The patch test was selectively performed when the lesions exhibited atypical features or a topical skin adhesive was not suspected to be the cause of dermatitis. Severe dermatitis from Dermabond (R) surgical glue As these values did not differ from those of all patients with possible risk factors (p=0.857 and 0.955, respectively), we concluded that previously known risk factors for type IV hypersensitivity did not significantly affect the incidence of ACD in topical skin adhesives. Burkemper NM. Contact Dermatitis. This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department. (n.d.). The next morning, with worsening erythema and itching, she was seen in the emergency room by the surgeon. Unauthorized use of these marks is strictly prohibited. Second, the patients in this study were confined to the application of topical skin adhesives to foot and ankle surgeries so that generalization of the results to the whole body can be questioned. The material is rapidly converted from a liquid to a solid state via polymerization at room temperature without the need for a catalyst, evaporation of a solvent or application of pressure [5]. Figure 2. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Vesicles similar to those seen with poison ivy were visible throughout all incisions, extending only to the area where Dermabond was applied (Figure 1). 0000059825 00000 n ct1qJq7?03Y1n`UA4/EQfcs&80.e` Thus, the increasingly large number of hysterectomies being performed with traditional laparoscopic and robotically-assisted laparoscopic techniques may contribute to a gross underestimation of the actual number accomplished. Inflamed skin should be treated with hydrocortisone 1% applied topically two to four times per day until reaction abates. Bethesda, MD 20894, Web Policies Statistical analyses were performed using SPSS (version 23.0; IBM, Armonk, NY, USA), and significance was set at p-value<0.05. Wright JD, Ananth CV, Lewin SN, Burke WM, Lu YS, et al. Join to Ask Your Questions and Receive Hysterectomy Checkpoints! Ask your HysterSisters. Received date: May 07, 2018 Accepted date: May 23, 2018 Published date: May 28, 2018. Having any kind of surgery means being exposed to many materials and medications. Coover and was marketed by the Eastman Kodak Company in 1958 as formulation Eastman 910 [9]. Physical examination of the surgical incision sites revealed that they were all clean dry and intact. Surg. and JavaScript. ), who has not used Dermabond since. A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations. Prog. Medicinal use of cyanoacrylate adhesives before FDA approval dates to the Vietnam War where field surgeons regularly used the formulation to quickly stop haemorrhage from skin wounds [10]. (2015). You can learn more about how we ensure our content is accurate and current by reading our. Contact Dermatitis and Medical Adhesives: A Review. However, there has never been a reported case resulting from use during gynaecologic surgery until now. The patient was advised to remove the skin adhesive with petroleum jelly and acetone. Abdomen of 63-year-old patient on post-operative day 7 with sudden onset erythema and pruritus surrounding the umbilical, left upper abdominal, left lower abdominal and right lower abdominal 5-mm trocar sites. Dermabond (1998) FDA, Summary of Safety and Effectiveness Data, Device Generic Name: Tissue Adhesive, Device. Thus, allergic reactions should only increase as laparoscopic and robotically assisted hysterectomy replace open abdominal and vaginal techniques. 0000012232 00000 n Gorski J, Chuang L (2018) Allergic reaction to Dermabond in gynaecologic surgery. In conclusion, ACD, while uncommon, occurs in 23% of patients who used 2-octyl cyanoacrylate or n-butyl cyanoacrylate topical skin adhesives. Ferguson, J. W., Tripathi, D. & Hayes, P. C. Review article: The management of acute variceal bleeding. FOIA No history of previous extended contact with acrylate glues, such as Superglue, artificial nail or eyelash adhesives or dental treatment requiring use of adhesives. Contact dermatitis, patch testing, and allergen avoidance. Background: The rash should go away completely within a few weeks. In short, jock itch can spread between, Keloids can appear on your ear in response to any type of wound, including a piercing. Blackmore, Sid Bookshelf Scott, G. R., Carson, C. L. & Borah, G. L. Dermabond skin closures for bilateral reduction mammaplasties: A review of 255 consecutive cases. 0000017967 00000 n 17, 670672 (2010). I had a rash covering my whole abdomen and anywhere they put that stuff, as well as on my thighs. Cochetti, G. et al. For wound dehiscence, adhesive tape was applied to the margins of the wound. 8600 Rockville Pike All the study protocol were conducted in accordance with the relevant guidelines and regulations (STROBE guidelines)18. %%EOF Ricci JA, Parekh NN, Desai NS. A maculopapular rash is a flat or raised red bump on the skin. Yoshimura, Kotaro hasContentIssue false, Correspondence: Joseph A. Ricci, MD Division of Plastic Surgery Brigham and Women's Hospital 75 Francis Street Boston, Massachusetts 02115 USA E-mail, Copyright World Association for Disaster and Emergency Medicine 2014. Jock itch and related conditions can cause discomfort and itchy, irritated skin. Continuous variables were analyzed with simple logistic regression, and categorical variables were analyzed using the chi-square test or Fisher exact test, as appropriate. Dermabond - allergic reaction Need Answers? From the Division of Plastic Surgery, Robert Wood Johnson Medical School, New Brunswick, NJ. 3Handschel JG Depprich RA Dirksen Det al. sharing sensitive information, make sure youre on a federal All incisions were erythematous and pruritic, but not tender. What Causes White Spots to Form on Your Nipple? 16 September 2014. She was afebrile. Dermabond is not used on areas such as the eyes and mouth. 105, 409420 (2000). Diffuse Cutaneous Allergic Reaction to Dermabond, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, Department of Physical Medicine and Rehabilitation, Thomas Jefferson University Hospital, Philadelphia, PennsylvaniaUSA, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, https://doi.org/10.1017/S1049023X14001010, Get access to the full version of this content by using one of the access options below. 0000001536 00000 n We aim to bring about a change in modern Although the use of topical skin adhesives has increased as an alternative to conventional skin closure methods, studies on the incidence and risk factors of allergic contact dermatitis (ACD) to topical skin adhesives have been limited. Does DERMABOND PRINEO System cause any allergic reactions? Mc Donald BS, Buckley DA (2014) Severe dermatitis from Dermabond surgical glue. . Concerns of tissue toxicity eventually excluded methyl 2-cyanoacrylate from use on human tissue [12]. The American Academy of Allergy, Asthma and Immunology shares that up to 20 percent of people have contact dermatitis. Please enable it to take advantage of the complete set of features! Contact dermatitis caused by dermabond advanced use. Care should be taken to apply Dermabond in thin layers to the edges of apposed skin with minimal seepage into the wound cavity. Osmond, M. H., Quinn, J. V., Sutcliffe, T., Jarmuske, M. & Klassen, T. P. A randomized, clinical trial comparing butylcyanoacrylate with octylcyanoacrylate in the management of selected pediatric facial lacerations. The .gov means its official. Dermabond is a skin adhesive used to close wounds, according to FamilyDoctor.org 2. ~%_W+`Su3-x3LX8pg u However, because n-butyl cyanoacrylate remains a viable option as a topical skin adhesive, the results of this study would be helpful for surgeons planning to use n-butyl cyanoacrylate topical skin adhesive. redness or discoloration, or visible rash, skin blisters that may drain fluid (especially if you scratch at the rash), a rash that appears quickly, spreads, and covers all or most of your body, shortness of breath or difficulty breathing, antibiotics if your rash is caused by an infection, prescription anti-inflammatory medications, a replacement medication if your rash was caused by a drug allergy. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. Wound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. Dermabond - allergic reaction | HysterSisters - HysterSisters Hysterectomy The .gov means its official. Shanmugam S, Wilkinson M (2012) Allergic contact dermatitis caused by a cyanoacrylate-containing false eyelash glue. Epub 2020 Sep 3. This decline has been attributed to the introduction of minimally invasive techniques such as uterine artery embolization for the treatment of leiomyomata and non-surgical ablative therapies that are now commonly used for abnormal benign uterine bleeding [1]. Incidence and risk factor of allergic contact dermatitis to 2-octyl Skin patch testing can be utilized to confirm clinical suspicion for an allergic reaction to Dermabond. 0000004181 00000 n Epub 2017 Jan 25. 2014. 2021. Oxford University Press is a department of the University of Oxford. Dermabond allergy is an extremely rare event. Post-surgery contact dermatitis is generally caused by an allergen or something that irritates your skin. The risk factors for ACD were identified using logistic regression analysis of odds ratios. 2021 Mar 24;13(3):e14090. As ACD occurs without risk factors in 23% of patients who used 2-octyl cyanoacrylate or n-butyl cyanoacrylate topical skin adhesives, clinicians and patients should be aware of these facts before using topical skin adhesives. Bone Jt. 0000061344 00000 n Perry AW, Sosin M (2009) Severe allergic reaction to Dermabond. : Systematic review. Fam. Severe Allergic Reaction to Dermabond - Oxford Academic The dermatologist made recommendation to apply a thin topical layer of hydrocortisone 1% to affected areas two to four times per day. Moschos M, Droutsas D, Boussalis P, Tsioulias G (1997) Clinical experience with cyanoacrylate tissue adhesive. Shaw, Daniel W. Allergic reaction to surgical glue | HysterSisters Reports have also described allergic contact dermatitis following application of cyanoacrylate-containing false eyelash glue [25,26]. Parkerson, Jamie Leggat, P. A., Smith, D. R. & Kedjarune, U. Surgical applications of cyanoacrylate adhesives: A review of toxicity. At-home therapies for eczema and dermatitis. After DERMABOND PRINEO System is applied, how will the surgeon assess whether the wound is healing Bhargava K, White JM, White IR (2012) Eyelid allergic contact dermatitis caused by ethyl cyanoacrylate-containing eyelash adhesive. Her incisions were closed with Dermabond. A prospective, randomized controlled trial comparing n-butyl cyanoacrylate tissue adhesive (LiquiBand) with sutures for skin closure after laparoscopic general surgical procedures. Use of cyanoacrylates for adhesive applications dates to their initial synthesis and patent in 1949 [8]. National Library of Medicine Dermatologist evaluation confirmed the suspicion of an allergic reaction to Dermabond and recommended application of a thin topical layer of hydrocortisone 1% to affected areas 2-4 times per day. The number is still staggering even though some estimate that the number of hysterectomies has been steadily declining over the last decade from a peak of 681,234 performed in 2002 to 433,621 cases reported in 2010. J. Yagnatovsky M, Pham H, Rokito A, Jazrawi L, Strauss E. Phys Sportsmed. A comparison of three methods of skin closure following repair of Achilles tendon rupture. Singer, A. J. Skin patch testing performed three years after initial presentation was positive for ethyl cyanoacrylate. Usatine, R. P. & Riojas, M. Diagnosis and management of contact dermatitis. government site. Immunol. 5, 101105 (2020). The Neuroanatomy of Poststroke Subjective Sensory Hypersensitivity. On postoperative day one, she was seen routinely and was well. Dermabond has rapidly disseminated to nearly every surgical specialty due to the unique ease of use. Gonzalo-Garijo MA, Perez-Calderon R, Perez-Rangel I, Sanchez-Vega S, Constantino JA (2009) Contact dermatitis after orthopaedic surgery. Singer, A. J. et al. J. Vasc. Surg. (2020). Dermabond () surgical glue had been applied to the skin at wound closure; the glue residue remained on the skin for several days. 6, 216222 (2014). Your doctor should be notified of any symptoms of infection, so treatment can begin immediately. Academic Pulmonary Sleep Medicine Physician Opportunity in Scenic Central Pennsylvania, MEDICAL MICROBIOLOGY AND CLINICAL LABORATORY MEDICINE PHYSICIAN, CLINICAL CHEMISTRY LABORATORY MEDICINE PHYSICIAN. See additional information. El-Dars LD, Chaudhury W, Hughes TM, Stone NM (2010) Allergic contact dermatitis to Dermabond after orthopaedic joint replacement. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Publication types Case Reports MeSH terms Breast Implantation / adverse effects Krishnan, R., MacNeil, S. D. & Malvankar-Mehta, M. S. Comparing sutures versus staples for skin closure after orthopaedic surgery: systematic review and meta-analysis. 0000031623 00000 n sustainable solutions for society. Embedded Dermabond may result in a foreign body reaction.8 This report describes contact dermatitis from the use of Dermabond. European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice. Although the use of topical skin adhesives has increased as an alternative to conventional skin closure methods, studies on the incidence and risk factors of ACD to topical skin adhesives have been limited. Acad. 0000055840 00000 n The time was significantly different between the two groups (P < .01). Emerg. She received perioperative cefazolin, and the implants were bathed in bacitracin. In a cohort study of 264,758 women who underwent hysterectomy for benign gynaecologic disorders at 441 hospitals across the United States from 2007 to 2010, the use of robotically assisted hysterectomy increased from 0.5% in 2007 to 9.5% of all hysterectomies in 2010 and laparoscopic hysterectomy rates increased from 24.3% to 30.5% [2]. In addition, the sutureless closure has become a marketing tool for surgeons. 2017. 2nd ed. The dermatologist diagnosed ACD based on history of exposure, morphology (well-demarcated pruritic eczematous eruptions, papules, or vesicles), and regional distribution (localized in the area of skin that was exposed to skin adhesives) (Fig. Sci. Postoperative results following the resolution of this allergic reaction are shown in Figure 3. The site is secure. Past medical history is significant for stage 0 DCIS, chronic hypertension and migraine headache. A., Schwartz, T. A. The purpose of this study was to investigate the incidence and risk factors of ACD after the use of 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. in four of eight patients tested, and to 2-hydroxyethyl methacrylate in one of eight patients tested. %PDF-1.7 % 0000010468 00000 n Sharma, A. et al. They will examine the rash itself, noting its size, shape, color, severity, and other characteristics. Get the most important science stories of the day, free in your inbox. The use of 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, NJ) for wound closure is increasingly popular. The substance was used as an industrial adhesive for metal, glass, rubber, and plastics since its introduction and eventually gained popularity in households as Superglue. Internet Explorer). 0000003918 00000 n 39, 12831289 (2018). A 63-year-old nulliparous female presented on post-operative day 7 status post total laparoscopic hysterectomy and bilateral salpingo-oophorectomy with sudden onset of erythema and pruritus around all four port site incisions (Figure 1). A methylprednisolone dose pack was prescribed (Medrol dose pack, Pfizer Inc., New York). volume11, Articlenumber:23762 (2021) Our community is filled with women who have been through the Hysterectomy experience providing both advice and support from our active members and moderators. Ricciardo BM, Nixon RL, Tam MM, Radic RR, Ricciardo BJ. Current knowledge assembled at an international workshop at BfR, Germany. 0000000016 00000 n 2-octyl cyanoacrylate should slough off naturally with desquamation of the epidermis 7-14 days after application [14]. government site. Article Hydrocortisone ointment was prescribed for the rash and to dissolve the Dermabond. A 36-year-old white woman on postoperative day four. 7 status post total laparoscopic hysterectomy and bilateral salpingo-oophorectomy with sudden onset of erythema and pruritus around all four port site incisions (Figure 1). Allergic contact dermatitis due to the liquid skin adhesive Dermabond Objectives, Submission, Review, & Disclaimer. Percutan Tech. Peiser, M. et al. Nine patients had positive patch test results to Dermabond; six had developed secondary generalization.The mean time between Dermabond application and ACD onset was 34 days (range, 27-44) in six patients with ACD after the first use, whereas, in the other three patients, it was 5.6 days (range, 4-8) after the second use. Pediatr Emerg Care. HHS Vulnerability Disclosure, Help Clinical photograph of a patient showing well-demarcated pruritic eczematous eruption, papules, and vesicles that developed in the skin area to which topical skin adhesive was applied. OA Texts journals are led by prominent To address this issue, we reviewed 1027 patients who underwent skin closure with 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives to investigate the incidence and risk factors of ACD to topical skin adhesives. 0000047688 00000 n Additional options for both kinds of post-surgical rashes include: Your doctor might decide to prescribe medications to treat your rash. Although there are only a few surgical cases reported regarding allergic reaction to topical application of 2-octyl cyanoacrylate, the current literature is rife with allergic reaction to other cyanoacrylate formulations especially when used during previous surgeries as outlined (Table 1) [13,15-24].